diff --git a/pkgs/applications/science/biology/bcftools/default.nix b/pkgs/applications/science/biology/bcftools/default.nix
index 97e081f908e..cfd72601d1e 100644
--- a/pkgs/applications/science/biology/bcftools/default.nix
+++ b/pkgs/applications/science/biology/bcftools/default.nix
@@ -3,12 +3,12 @@
 stdenv.mkDerivation rec {
   name = "${pname}-${version}";
   pname = "bcftools";
-  major = "1.4";
+  major = "1.5";
   version = "${major}.0";
 
   src = fetchurl {
     url = "https://github.com/samtools/bcftools/releases/download/${major}/bcftools-${major}.tar.bz2";
-    sha256 = "0k93mq3lf73dch81p4zxi0bdll567acxfa81qzbzkqflgsjb1ccg";
+    sha256 = "0093hkkvxmbwfaa7905s6185jymynvg42kq6sxv7fili11l5mxwz";
   };
 
   buildInputs = [ zlib bzip2 lzma perl ];
diff --git a/pkgs/applications/science/biology/samtools/default.nix b/pkgs/applications/science/biology/samtools/default.nix
index 827c1448693..f8391a2d6b3 100644
--- a/pkgs/applications/science/biology/samtools/default.nix
+++ b/pkgs/applications/science/biology/samtools/default.nix
@@ -3,12 +3,12 @@
 stdenv.mkDerivation rec {
   name = "${pname}-${version}";
   pname = "samtools";
-  major = "1.4";
+  major = "1.5";
   version = "${major}.0";
 
   src = fetchurl {
     url = "https://github.com/samtools/samtools/releases/download/${major}/samtools-${major}.tar.bz2";
-    sha256 = "1x73c0lxvd58ghrmaqqyp56z7bkmp28a71fk4ap82j976pw5pbls";
+    sha256 = "1xidmv0jmfy7l0kb32hdnlshcxgzi1hmygvig0cqrq1fhckdlhl5";
   };
 
   buildInputs = [ zlib ncurses ];
diff --git a/pkgs/development/libraries/science/biology/htslib/default.nix b/pkgs/development/libraries/science/biology/htslib/default.nix
index a74905b5ba1..5a08e32e7e9 100644
--- a/pkgs/development/libraries/science/biology/htslib/default.nix
+++ b/pkgs/development/libraries/science/biology/htslib/default.nix
@@ -4,11 +4,11 @@ stdenv.mkDerivation rec {
   name = "${pname}-${version}";
   version = "${major}.0";
   pname = "htslib";
-  major = "1.4";
+  major = "1.5";
 
   src = fetchurl {
     url = "https://github.com/samtools/htslib/releases/download/${major}/htslib-${major}.tar.bz2";
-    sha256 = "0l1ki3sqfhawfn7fx9v7i2pm725jki4c5zij9j96xka5zwc8iz2w";
+    sha256 = "0bcjmnbwp2bib1z1bkrp95w9v2syzdwdfqww10mkb1hxlmg52ax0";
   };
 
   buildInputs = [ zlib bzip2 lzma curl ];