94 lines
4.3 KiB
Plaintext
94 lines
4.3 KiB
Plaintext
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BRAIN DAMAGE AND MDMA
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Two studies were used as evidence to support the emergency placement
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of MDMA into Schedule I effective July 1, 1985. These were Woolverton
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et al. and Ricaurte et al. (See references). The latter study was
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not even done with MDMA, but rather with MDA. The DEA also recieved
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a study from another group (Schmidt, Wu, and Lovenberg) done using
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MDMA. I have not yet looked up the MDA paper, but I did find the
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Schmidt, Wu, and Lovenberg paper (actually, it's only an abstract) and
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I have some information on the still unpublished Woolverton et al. paper
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from another reference (Shulgin, A.T.). The Woolverton et al. paper
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should come out this year in a book.
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In the Schmidt, Wu, and Lovenberg study rats were given single injec-
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tions (s.c.) of MDMA and killed 3 hours later to measure concentrations
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of brain metabolites. From previous studies they knew that serotonin
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levels decline and reach their minimum concentrations at 3 hours. Rats
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given 2.5, 5, 10, and 20 mg/kg MDMA had striatial serotonin concentrations
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that were 97%, 40%, 25%, and 25% of control rats 3 hrs. later. One week
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after injection rats given 10 or 20 mg/kg MDMA still had "significantly
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depressed" levels of serotonin. They don't say what the levels were,
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though.
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Rats in the Woolverton et al. study were either injected twice daily
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for four days with MDMA and killed two weeks later, or they were given
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one dose and killed two weeks later. The dosages were 10, 20, 30, or
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40 mg/kg. Rats that went on the MDMA binge all had "extensive decrease"
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of hippocampal serotonin. A single injection at 40 mg/kg lowered sero-
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tonin levels to 76% of just-say-no rats two weeks later.
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What does this mean to those of us who are not rats? Well, if you are
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a Rhesus monkey, it means that if you take twice the lethal dose of
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MDMA (LD 50 in Rhesus monkeys is 22 mg/kg) and survive, you will only
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have serotonin levels that are 76% of your friends' who told you not
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to do it. If you are sort of like a Rhesus monkey (like me) then it
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means you can probably safely take 2.5 mg/kg of MDMA (orally, please)
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and suffer only a 3% or so temporary drop in your serotonin levels.
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For a 150 lb. human, 2.5 mg/kg is 170 mg. Most street doses are about
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100 to 150 mg. Anyway, these studies will probably turn out to be
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poorly done just like the ones done on LSD several years ago that
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concluded that LSD caused chromosome damage. It turned out that if
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you leave heavy amphetamine users out of the study, there is no evidence
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of chromosome damage. Yes, I know, MDMA is an amphetamine. It just
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means that you shouldn't overdo it. Even peanut butter has mutagens
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in it (aflatoxins).
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Hugs and Kisses,
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Betelnut (Wierdo7)
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REFERENCES
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Ricaurte, G.; Bryan, G.; Strauss, L.; Seiden, L.; and Schuster, C. 1985.
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Hallucinogenic amphetamine selectively destroys brain serotonin
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nerve terminals. Science Vol. 229:986-988.
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Schmidt, C.J. and Lovenberg, W. 1986. (+/-) Methylenedioxymethamphet-
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amine (MDMA): A potentially neurotoxic amphetamine analog. (Abstract
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5264). Federation Proceedings Vol. 45: 1059.
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Shulgin, A.T. 1986. The background and chemistry of MDMA. Journal of
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Psychoactive Drugs Vol. 18(4): 291-304.
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Woolverton, W.L. et al. 1985. Behavioral and neurotoxic effects of
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MDMA and MDA. Abstract from the American College of Neuropsycho-
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pharmacology Meeting, Honolulu.
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From Lunatic Labs UnLtd. 415-278-7421
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